p5p prolactin reddit. so im happy to report back the p5p cycles was a success. Vitamin B6 as a potent Prolactin Inhibitor, possible AI? : r/Testosterone. Reduce prolactin with Mucuna Pruriens. It appears Vitamin B-6 in its pure form (called p5p) helps reduce prolactin as well. its a gradual process but it effectively lowered my prolactin. This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase. Got a blood test from my endocrinologist and testosterone and thyroid markers are within range, . 5 ng/ml, blood work before cycles I'm usually around 11 ng/ml and really don't show any signs of high prolactin below 18 Just my experience, but again caber is cheaper to use than P5P regardless. calcium d glucarate for e2 and P5P for prolactin, since starting P5P prolactin has . L-Tryptophan’s role in brain serotonin synthesis is critical for mood, behavior and cognition. Recommended dosage for bringing down prolactin using P5P? nsfw Got my blood test today and prolactin level at 236mIU/L (11. High cortisol from stress or inflammation (think gut health again); High prolactin; Inadequate nutrition or excess sugar. But certainly I have not had any hints of gynecomastia (which high prolactin can cause in men) on this very low dose regimen, over the 3+ years that I have been taking 12. I've been taking P5P 50 mg/day + d-alpha Vitamin E 400 IU/day for 6 weeks now. Studies have also shown that Mucuna Pruriens lower cortisol levels and boost mood. Most people run 100-400 mg/day P5P and keep prolactin well I’m check. Please go to /r/steroids for information about steroids, /r/peptides or datbtrue forums for. Assuming that Prolactin is in Range or Managed with 200-300mg Vitamin B6 P5P per Day and Progestogenic AAS are not Part of the PED Protocol, the Following Protocol should be Highly Effective to Restore Libido: • 1,000-2,000iu HCG (depending on Potency) Every other Day; for 2-3 Weeks or 7-10 Injections Total. Mucuna Pruriens is one of rare herb that contains L-dopa. So P5P is the active night form of Vitamin B6. Vitamin B6 is an effective prolactin inhibitor that is extremely cheap and safe. Six-week old male rats were maintained for 4 weeks on a vitamin B6-free diet to cause a moderately severe degree of vitamin B6 depletion. I take one pill a day of that and DIM for estrogen. Although in a lot of cases I think prolactin needs to get really high (like triple digits) to cause very low levels of testosterone. I take between 50mg and 100mg a night depending on what compounds I'm using. Secondary Prolactin Inhibitor Supplements: 1) Ginseng extract-‘Rats treated with American ginseng exhibit an approximate 50% reduction in serum prolactin’! 2) Maca powder. Agree with @gondar1, try P5P or go one step further and buy injectable b-6. 25mg caber twice a week and bloods had my prolactin at 14 ng/ml With P5P was at 18. Mucuna Pruriens is well-studied to raise testosterone levels and reduce prolactin levels. Vitamin B6, also called pyridoxine, pyridoxal 5-phosphate, or P5P helps to relieve premenstrual symptoms via several mechanisms: It’s involved in the synthesis of steroid hormones, particularly progesterone. I managed to find only supplements with 50mg, not less. Okay now, there are 3 vitamins that can be combined to reduce prolactin levels pretty efficiently. Read the label before you buy B6 because the Pyridoxine Hydrochloride type of B6 (in. Your body converts b6 into p5p but you can also take p5p directly. Normal weight, glucose/insulin wnl, Thyroid wnl, prolactin wnl Vitamin B6 (P5P) – 25-100mg P5P. Mucuna Pruriens is a very interesting herb native from Africa and Asian. d-alpha Vitamin E: 400IU 1x/day . I have been experiencing reduced libido and energy for a while so I went to see the doc and had some blood work done. Testerone level flunctuations is expected, but not to the degree u have observed. After the vitamin E treatment . The rise in dopamine lowers prolactin [43]. It won't lower prolactin much after its already high apparently. I heard this with B6 (inactive form) that it cause neuropathy but apparently P5P is safer. P5P is needed for the production of melatonin, also known as the sleep hormone. If you are suffering with trigger finger, you need to see this video. Had some bloodwork done last week. It slightly reduces your prolactin, however it won't do anything to gyno. Any thoughts on what's causing prolactin levels to be elevated, or how to treat? I'm ordering some P5P to start. Currently injecting 3x per week and taking. 45 SHBG - 18 I immediately started taking adex and lowering my test dose. 5-HTP products may contain contaminants or increase levels of prolactin, . I have strictly prolactin based gyno, . Last night, in addition to my new routine of 400mcg methylfolate and 250mcg B12, I also took 120mg of B6 (I am taking it for feminine problems. I have heard some people also combine B6 / P5P with Vitamin E and Sam-e for an even more potent . Prolactin and Libido: Too Much (or Too Little) Can. I have them saved if anyone wants to see them. I have seen plenty blood-work and . Maybe take lower doses of P5P if its giving you issues. I also take p5p to increase dopamine, serotonin and lower prolactin. One pilot study suggests they might be right. Ment / test cycle and how much AI?. After your earlier message about prolactin, I did some research. Don't forget your Vitamin E, also good for controlling prolactin. P5P is a coenzyme, meaning that it works with enzymes to help them accomplish their tasks more quickly and efficiently and thus is a crucial element of biosynthesis. You can however use a activated b6 form like p5p to avoid the issues. Dec 28, 2020 #1 Anybody here using p5p to control. So using P5P 100-200mg and 500mg of Pure L-Dopa extract(1 microscoop), can significantly help in the lowering and control of prolactin. I should of taken P5P before starting my NPP cycle because that is how you get P5P to work( @Jestopherson)to lower prolactin and keep it low. While continuing with Vitamin E at 400iu per day, and 300/400mg of Vitamin B6 per day, split into 2 divided doses. Can massive doses of vitamin B6 and/or B. I've given up on reducing my prolactin and just living with it. I just ran bloods and my Prolactin came at 28 ng/mL. I have been struggling with neuropathy and body malaise. Welcome to Sarm Source Talk! This board serves as a place where users can discuss sarm, peptide, and research chemical sources. 7 in 3 months, using 50mg of P5P, and then in another 7 months his prolactin came back at 6. uodate: successfully lowered my prolactin with P5P successfully dropped it to around 200 (whichever the measurement it is i cant remember. Prolactin can cause low T, as in the case of a prolactin-secreting tumor which causes very high levels. My question is, will I need caber? or at. Got referred to a urologist and took a second test, again similarly came back free 37. Bromocriptine, a dopamine agonist, is efficacious in lowering elevated . In simple words, rise in testosterone/estrogen makes you feel horny (arousal), which if followed by sexual activity, will lead to a rise in prolactin to negate the initial stimulus (arousal) produced by testosterone/estrogen. >By Max : This is important to realize! It is only going to work during the use of Mucuna Pruriens Extract for L-Dopa 15-99% pure. Search this forum lots of info on P5P, high doses have some really bad side effects I believe (neurological). Balding cure reddit Hair loss isn't limited to the male population. I’m at 300 mg npp per week and 600 testosterone per week. This led to a significant reduction in the circulating concentration of testosterone in plasma (control = 8. My TSH has always been between 1-2, never this high. Facebook Twitter Reddit Pinterest Tumblr WhatsApp. Ginkgo improves the dopamine levels in the human body, while acting as a prolactin inhibitor. So, treatment with P5P may be preferable for most cases. Other than things like Prami or Caber, there isn't much . I took some P5P, 50mg today and 50mg yesterday, with great effects. Thread starter Lter1987; Start date Dec 28, 2020; L. Messages 15 Reaction score 2 Points 3. I previously posted my bloods showing high prolactin and complained of erection diffs. But it's been a year since I stopped fertility treatment and I've been back Androgel since. High prolactin, e2 somewhat high, would an ai help? Or should I look into caber. Despite my Prolactin being slightly raised. Not cost effective but if you can not take bromo or prami, then will help. Vitamin B6 (Pyridoxine, Pyridoxal, Pyridoxamine) is one of 8 B-vitamins. In fact, the reason that high dose B6 causes nerve problems is that the body can***8217;t always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P. Bodybuilders report benefits from P-5-P during or after cycles. P5P plays an important role in various functions in the body such as metabolism at the cellular level, muscle growth and repair, mood. My side’s are two or three zits per week and half A adex. As an added bonus, vitamin B6 has been seen to help increase sperm count in men with low levels. Everything else in his protocol remained unchanged. Primary Prolactin Inhibitor Supplements: 1) Vitamin B6. I got my latest bloodwork and my prolactin levels are still over range. A guy I talk to from a TRT fb group lowered his prolactin from 22. I'm going with 100 deca and 200 test cyp for the first month and see how it feels from there. I just purchased this supplement which says . Research hasn’t found a direct link between P-5-P levels and insomnia, but taking vitamin B6 before bed increased melatonin release from the pineal gland in a study of 120 children [ 39, 40, 41 ]. Tryptophan has been shown to help alleviate anxiety, depression, ADHD, SAD, OCD, PMS, memory loss, and pain. interested to hear from others, cheers!!!. How to reduce prolactin with p-5-p?. If it is prolactin, try taking 200-300mg P5P (it's the active form of vitamin B6). I should say that I always stop ejaculating 2 days before the test to avoid Prolactin spikes. Treatment consists of lowering the prolactin level by medication or surgery, or both. The resounding advice was to lower Prolactin with P5P - unfortunately 100mg per day gave me wicked insomnia after just 2 days I kept trying to restart after stopping it for a couple days until insomnia let up but each time it would return after 2 days…. P5P (active form of Vitamin B6): 50mg 2x/day - study showing an average prolactin reduction of 25. You should probably dose it 3 times per day. Since the studies on B6 and prolactin on PubMed are mostly from the 1970s and 1980s the authors used the Hcl salt due to cost concerns since P5P was apparently very expensive at the time. Blood worked showed high prolactin? Any suggestions on. Don't do this dose as a long term solution, you'll get sides from over dosing vitb. I think we all know what causes estrogen to rise, but as for prolactin these cause it to rise: tumors, chronic stress, too much masturbation, opiates, antipsychotic meds, meds that raise serotonin (ssri, etc). I am sure I posted it here in the health section. P5P at 300mg a day alone brought my prolactin from a 468 to a 250 while running LGD over an 8 week period. I'm cautiously optimistic as often supplements are great to start with then go downhill. We read constantly about Deca, Tren, and NPP raising prolactin and how it's best combated with caber, prami, or P5P/B6. There are studies that indicate oral B-6 did as well as caber for prolactin control in women. So I was looking up P5P, regarding lowering prolactin, and then stumbled upon articles showing that P5P may lower GH secretion, and that Cabergoline definitely lowers GH secretion. According to some theories, it should also help with premature ejaculation, by reducing prolactin - do you have any experience with this. I read in a few places that p5p (vitamin b6) can help reduce prolactin, and with it gyno. I’m getting leaner as im putting on lean mass not bloat and my vascularity is coming in nice. This subreddit is for questions and discussion related . Could be liver damage or lack of protein. I started P5P (B6) With vit e for prolactin. Recommended dosage for bringing down prolactin using P5P. Research hasn't found a direct link between P-5-P levels and insomnia, but taking vitamin B6 before bed increased melatonin release from the pineal gland in a study of 120 children [ 39, 40, 41 ]. We encourage our users to share their experiences and ask questions relating to sources and their products. WRT P5P and L-Dopa Dissociation of growth hormone and prolactin response to levodopa during pyridoxine administration. Guys, My TRT doc has given me pharma grade Deca for my constant joint pains and asked me to add 100-200mg to my TRT cycle. So i would like to know if anyone has documented high prolactin that gets post nasal drip and also how they have treated prolactin problem. Pyridoxal phosphate or P-5-P is the active form of vitamin B6, a crucial nutrient for physical and mental health. Everything written here was advice from a medical director who does take steroids himself. After taking the P5P the issues seemed to lift a bit and I felt more myself, more calm but energetic. P5P is a lot more effective at lowering prolactin than b6 because you can take significantly lower dose. this guy using pt-141 has bloodwork done every month and since he started using pt-141 his prolactin has gone down by 80%. P5p dosage for prolactin Reddit Prolactin-Inhibiting Supplements - reddi. B 6 is water-soluble and found in every single cell in your body. I know many think b6 works for prolactin related gyno. However I would love to hear from you about how I can get dostinex. I doubt I keep taking it daily before long. i have not noticed any difference but i have been taking it for two days so. Nowadays you can find P5P at much more reasonable prices and not much more expensive than the Hcl salt. Vitamin E to Lower Prolactin? : Testosterone. I recommend that anyone taking any sort of steroid that will cause prolactin related side effects supplement the natural way with P5P to avoid having to go the pharmaceutical route unless needed. Mucuna pruriens; Zinc; Ginkgo Biloba. 1 day after an injection if 125mg test, 150mg npp, and 150mg mast. Basically its the zma stack, I also add vit E which is also good for prolactin control. P5P to counteract REALLY HIGH prolactin induced gyno?. :but are you really gonna trust Share: Twitter Reddit WhatsApp Email Share Link. ) Soon after, when lying in bed, I started feeling really agitated and spacey and I was having trouble focusing and seeing - like there was a bit of. But when I found another two vitamins to stack with it to increase efficiency, I just had to share. As well as a ldopa supplement (prolactrone). All of the added ingredients in the mix have been sourced naturally and can be used safely for prolonged durations without. I’ve read so many things about npp gyno and want your guys opinions. 85K subscribers in the Testosterone community. The sides I know of from b6 should all disappear when the high dosing does. Hey guys as per requested I'm posting my bloods for my current cycle of 250mg test e, 450mg npp, and 300 mast e. Vitamin B 6 a required coenzyme for the synthesis of dopamine, epinephrine, GABA. first cycle it halved it, after my 2nd cycle i felt better overall too however i neglected to get my prolactin tested. Going to have follow up labs on my e2, prolactin, and a full thyroid panel in one month. Anyway bloods have come back showing High LH, High Test, High Prolactin, High SHBG. Sometimes the otc option is not enough, and if prolactin sides still exist, you will have to get prami or caber. I read some posts about p5p lowering prolactin and i was wondering if theres any other really effective supplements to reduce the . Even on TRT my prolactin is about 20 - 22 unless I take P5P or Cabergoline. 9 and total of 204, so we talk about options and right away am relieved that the doc was the one to recommend subq injections. Hundreds of guys on reddit swear by P-5-P for managing prolactin on NPP & Tren for doses up to 500mg/week. Vitamin B6 helps keep your prolactin and your sex life at optimal levels. As a supplement, P-5-P is promoted to deliver greater benefits with fewer side effects, but there’s no clinical evidence to back this up. You might want to see an endo and do an MRI like touchemestepthru said. As far as prolactin, I stopped retaining a bunch of water and my breasts were not swollen and sore. I use P5P w/Magnesium, along with my Zinc. Testosterone: The male sex hormone. Vitamin B6 is known to enhance alertness, cognition, energy, elevate mood, lower anxiety and normalize homocysteine levels. Further, nice side effects will be improved mood/libido, increased . At first I took 200mg in one dose and that seemed to lower prolactin a lot, BUT it also gave me extreme anxiety and feelings of being spaced out. Caber is cheaper to use and bloods prove working, 600mg npp a week and. Going into primary asked to have T looked at, came back free at 38 and total at 197. And you’re much better off/safer running P5P for prolactin reduction. Have ED, low libido, low ejaculate. According to some theories, it should also help with premature ejaculation, by reducing prolactin - do you have any experience with this? I know that B6 (therefore I think also P5P) overdose is a real risk and it can cause neuropathy. Hi guys, I'd like to supplement P-5-P, since I've read it could help with brain fog, focus, overall energy and motivation, by boosting dopamine production. i am using P5P (form of b6) as suggested by others to lower prolactinbut what is the dosage? and if P5P has helped you lower prolactin, please let us know your info. Knowing I had deca dick absolutely did not solve the problem though and I also did not like taking caber for it. Long-Term Nandrolone and Testosterone. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in all patients before and after treatment. I never get gyno but it would suppress dopamine and make me all flat in mood and physique and libido. I too suffered from trigger finger, to the point were my quality of life was severely i. You really shouldn't need something stronger unless you are taking prolactin inducing steroids or have a . Vitamin B6 (Pyridoxine Hydrochloride & P5P). Anyways, I took P5P several times in the last month and I have to say that it works but finding the right dosage has not been easy for me. Suggested dose is 100mg twice per day. Not off the charts high, but I would at least like it at high normal. Hyperprolactinaemia (high blood prolactin levels). He showed me his labs and everything. I have not had my prolactin levels tested, but I have noticed that my libido is lowered from amisulpride. It will contain two ingredients clinically use to reduce prolactin. When you combine B6 with L-Dopa it does in fact enhance this conversion but it makes more of it happen. My prolactin is pretty high from tren and opiates. Among other things, I found studies showing that . Effect of zinc supplementation on hyperprolactinaemia in uraemic men - PubMed. Since that is more natural , I ordered that already. Vitamin B6 in P5P form and vitamin E instead. That would explain the erection and sex drive increase Dec 13, 2021. As a supplement, P-5-P is promoted to deliver greater benefits with fewer side effects, but there's no clinical evidence to back this up. Black Lion Research Rep Brain5ick. 25 twice per week and get bloodwork after a couple weeks. omgbossis34 said: High doses of b6 can cause issues, nerve issues in the fingers and hands being most notable if I recall properly. but ill give an update of whats going on with me since cycling p5p twice. Is it a too high dose to take everyday?. This enzyme is responsible for the . ADHD may be simply a vitamin B6 deficiency. The specialists at the clinic weren't worried about it. I waited about a week and then took 100mg in one dose. Increased target tissue uptake of, and sensitivity to. i took p5p for 1 month, then checked bloodwork again, it said my prolactin level was around 450 or 480, so that was a clear sign the prolactin was decreasing, still on the upper end of the prolactin scale, so i figured id need to do another month of p5p, so i did. They work, they have a lot do positive effects beyond the above. And also that 19 Nors should never be used alone. Prolactin is a hormone produced by the pituitary gland in both men and women. Anecdotally, it helps prevent gynecomastia (abnormal breast growth) by lowering prolactin levels. This hormone is best-known for its role during pregnancy and breastfeeding when levels rise to up to 20 times higher than normal due to its role in producing breast milk. So I've been reading people use up to 200mg of P5P to lower or regulate their prolactin levels. Im on my 6th week and making nice progress. Prolactin, when it comes to sexual activity, is a hormone that counteracts the effects of testosterone (in men) and estrogen (in females). Zinc-treated patients had significantly higher plasma zinc levels (134 +/- 10 micrograms/dl v 88 +/- 2 micrograms/dl) and. at its peak i think it was around 1000. 092ng/mL), I want to bring it down to a lot lower for energy reasons and also to reduce refractory period after sex. Preliminary evidence found that vitamin B6 restored menstruation and normalized hormone levels in three women with amenorrhea who had high prolactin levels. This may be due to raised prolactin. According to animal and human studies, it's generally noted that vitamin B6 have a suppressing effect on prolactin levels. I've heard a whole lot about B6, but not about the active form of B6 (P5P). A zinc supplement may also help lower your prolactin levels. So I am hoping my prolactin levels will gradually reduce as time goes on. I've read that but I've been experimenting with all different doses of B6 and P5P and never got the effect I got when I first started B6. A good cocktail would be : P5P, vitamin E and D. The only ancillary I was running was p5p at 200mg every day. Bromo is easy to get and cheap. theres also drugs like bromocriptine and dostinex. P5P to decrease prolactin? dosage? i have high prolactin, it's 40. 4 ) SHBG: 51nmol/L (ref range 16 - 55 ) Free androgen index: unable to calculate. Now I am thinking that the mechanism of these products that lower prolactin may actually reduce the effectiveness of MK677. I take 2 tablespoons of ACV in water each morning and have cleared up my post nasal drip that doctors could never heal, cured. 25mg adex EOD Results: Testosterone: 52. But as mentioned it will take a while to slowly clear my system, so it will probably still keep prolactin levels elevated until it clears. Serotonin is often referred to as the “happiness molecule”. Prolactin levels is something u should try to fix with p5p or SamE (vitamin E). The B6/vit e helps keep a smoother tighter look. One day on p5p and I feel great again. Was taking 400 mg x2 per day and prolactin still went up to double the reference range. Also looking to maybe increase T dose to get it into the 800s or so. To lower prolactin levels it's recommend you take 50-200 mg of P. Hi guys, not sure which topic this one of supposed to go in. i have heard that active b6 called p5p can help in doses of 300mg a day. Normal range for labcorp is 4-15,mine was 21. Since it is the active form of B6, recommended that smaller doses are used, you could experiment with half a tab ~10mg. I just barely figured this out, cuz I was having prolactin problems on MK677 too. That sucks it didn’t work for you - I hear mixed things online about whether. Sam-e for prolactin control/depression. In fact, the reason that high dose B6 causes nerve problems is that the body can't always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P. This is another natural way about how to reduce prolactin. My level has been like 20-25ng/ml throughout TRT. Low testosterone in MEN: PHYSICAL SIGNS AND SYMPTOMS * Erectile dysfunction (impotence: inability to develop or maintain an erection) * Fatigue (lack of . Tryptophan is the sole precursor of serotonin. higher serotonin is linked to high prolactin. Cabergoline just complicates my E2/testosterone balance too much. But I ran across a post recently (used the study listed below) asserting 19 Nors alone don't raise prolactin, and can even reduce it, based on human trials in 1980. P5p dosage for prolactin Reddit Prolactin-Inhibiting Supplements - reddi In fact, the reason that high dose B6 causes nerve problems is that the body can't always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P. Recommended dosage: To lower prolactin levels I would recommend you take 50 to 200mg of P5P a day, in divided doses. it exerts hypothalamic dopaminergic effect which causes a significant reduction in prolactin level. Vitex has the ability to reduce the elevated levels of prolactin. SNS Inhibit-P is an all new health supplement that contains a highly precise blend of Prolactin Control Complex (PCP) that may help lower prolactin production, increase dopamine levels, and improve feelings of well-being. New bloods in, very high prolactin and somewhat high e2. What are the symptoms of having low testosterone?. It isn't expensive and you just take a slin pin shot a day for whatever dose you want. Second, we did not study the free testosterone, luteinizing hormone, or prolactin levels to explain the evidence on the relationship between vitamin D and . Men diagnosed with high prolactin levels (hyperprolactinemia) often complain of loss of libido and erectile dysfunction (ED). If you want to take regular B6, which as I've mentioned can sometimes cause minor side effects, take 300 to 1000 mg per day in divided doses. Ive done two 1 month cycles of P5P at 200mg a day. These two forms need to be converted to its active form, pyridoxal 5 phosphate (PLP), by the enzyme, pyridoxal kinase, for it to perform its . Effects of zinc on prolactin. So those 2 supplements didn't help me at all. P5P Supplementation And Prolactin. Looking for some guidance on my blood test results, 8 weeks into my cycle. Depending on the study you read, P5P is as or more effective at lowering prolactin than caber and has no sides under about 800mg/day. The levels of the hormones testosterone and dopamine fall post orgasm and the pituitary gland produced hormone prolactin rises. Bro get p5p which is a form of vitamin b6. These were the numbers I got: Total Test: 724 (Range 200-850) Free Test: 13 (Range 9-21) Prolactin: 21. Lowering prolactin levels : r/moreplatesmoredates. The urea level is very low for someone who goes to the gym, as id expect it to be higher if u are also taking protein. Everything came back pretty solid for the most part except prolactin. If so what dosages where you taking. Dosing for P5P would be about 100 to 200mg daily, since it is the active form you don’t need as much and the side effects will be minimal if at all. C apsules (gelatin, glycerin, water), soybean oil. So I thought I must have high prolactin levels and searched for something that could lower it. This test was taken at the beginning of week 5. On 100mg test E split everyday injections and added calcium d glucarate for e2 and P5P for prolactin, since starting P5P prolactin has increased from 19-27. If I start getting obvious high prolactin sides (such as leaky nips) I will dose caber. Once vitamin B6 is converted to P-5-P, it increases dopamine in the brain. It’s essential for the manufacture of brain neurotransmitters, including GABA, dopamine, and serotonin. It won't work miracles but it can help. P5P supplements can help with high prolactin. Zinc and prolactin levels were measured in 32 male haemodialysis patients; 12 were receiving 50 mg zinc per day as zinc acetate and 20 were not. Start with 60 to 360 mg a day, adjusting the dose depending on the results. Other results were Total test - 875 Estradiol - 24 LH - 8. After two or three months on the P5P I started noticing numbness indicating nerve damage, which is a side effect of high dose P5P.